Multivariable logistic regression was used. At 5 years of age the child´s history of asthma, eczema and food allergy, including atopic heredity, was reported by questionnaire. Maternal dietary vitamin D intake was estimated from a short food frequency questionnaire and supplement use by questionnaires. Participants in the GraviD study had 25-hydroxyvitamin D (25OHD) analyzed in serum in early (T1) and late (T3) pregnancy.
In addition, effect modification by reported atopic heredity was studied. Thus, the aim was to investigate the associations between maternal vitamin D status and intake in pregnancy with asthma, eczema and food allergies in the children up to 5 years. In contrast, others have found a higher maternal 25OHD to be related to a higher risk of atopic diseases. Previous studies have found an inverse relation between maternal vitamin D in pregnancy and the risk of atopic diseases in the child. The relationship between maternal vitamin D status in pregnancy and the development of atopic diseases in the offspring has been frequently studied, but with contradictory results.
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